Drugs that have restrictions other than prior authorization, quantity restrictions, and stage therapy involved with each prescription.

enzalutamide will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead into a minimize in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, enhancement of a withdrawal syndrome in the patient who may have produced Actual physical dependence to fentanyl.

Keep track of Closely (1)istradefylline will raise the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism.

fentanyl will raise the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. If coadministration of lonafarnib (a delicate CYP3A substrate) with weak CYP3A inhibitors is unavoidable, decrease to, or keep on lonafarnib at beginning dose.

If coadministration of CYP3A4 inhibitors with fentanyl is necessary, watch patients for respiratory depression and sedation at Recurrent intervals and consider fentanyl dose adjustments until finally stable drug effects are obtained.

Check Carefully (one)pentobarbital will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to a reduce in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, development of a withdrawal syndrome in a very affected individual who has created physical dependence to fentanyl. After stopping a CYP3A4 inducer, as being the effects of your inducer drop, the fentanyl plasma concentration will increase which could boost or prolong both equally the therapeutic and adverse effects.

If coadministration of CYP3A4 inhibitors with fentanyl is essential, watch patients for respiratory depression and sedation at Repeated intervals and consider fentanyl dose fentanyl addiction risks adjustments right up until stable drug effects are attained.

asenapine transdermal and fentanyl both equally boost sedation. Keep away from or Use Alternate Drug. Limit use to patients for whom alternative treatment options are insufficient

Observe Intently (1)mitotane will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead to a lessen in fentanyl plasma concentrations, insufficient efficacy or, possibly, progress of a withdrawal syndrome inside of a individual that has developed Bodily dependence to fentanyl.

Watch Closely (one)nafcillin will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to a lower in fentanyl plasma concentrations, insufficient efficacy or, quite possibly, advancement of a withdrawal syndrome within a affected individual that has designed Actual physical dependence to fentanyl.

pentazocine decreases effects of fentanyl by pharmacodynamic antagonism. Steer clear of or Use Alternate Drug. Coadministration of mixed agonist/antagonist and partial agonist opioid analgesics may possibly lower fentanyl's analgesic effect And maybe precipitate withdrawal symptoms.

buprenorphine transdermal and fentanyl both maximize sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom substitute treatment options are insufficient

anastrozole will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.

fentanyl and fentanyl transdermal equally raise sedation. Avoid or Use Alternate Drug. Restrict use to patients for whom alternative treatment options are inadequate